研究開発

技術内容

1) mRNA delivery technology

Conventional Technology
Protein production in a cell
Protein production in a cell
Merits of mRNA therapeutics
  • Applicable to various proteins
  • No genome damage
  • Applicable to non-dividing cells
  • Relatively long-lasting protein production
Challenges of mRNA therapeutics
  • Instability in mRNA (esp. naked mRNA)
  • Inflammation
  • Low delivery efficacy
AccuRna's Technology
Encapsulation of mRNA into a micelle
Encapsulation of mRNA into a micelle
Merits of the micelle delivery of mRNA
  • Stabilization of mRNA
  • Inflammatory suppression
  • Increasing delivery efficacy
Exemplary therapeutic effect of micelle delivery of mRNA
Exemplary therapeutic effect of micelle delivery of mRNA
Data is from the University of Tokyo

2) siRNA delivery technology

Conventional Technology
RNA interference
RNA interference
Merits of siRNA therapeutics
  • Sequence-specific suppression of gene expression
  • No genome damage
  • Chemical production of siRNA
Challenges of siRNA therapeutics
  • Difficulty of tumor targeting
  • Inflammation
  • Toxicity of an siRNA carrier
  • Low retentivity in blood  
  • Difficult production process of siRNA formulation
AccuRna's Technology
Encapsulation of siRNA into a unit PIC
Encapsulation of mRNA into a micelle
Merits of the unit PIC delivery of siRNA
  • Accumulation of siRNA into a tumor
  • Inflammatory suppression
  • Low toxicity of the unit PIC
  • Improved retentivity in blood
  • Simple preparation
Exemplary therapeutic effect of unit PIC delivery of siRNA
Exemplary therapeutic effect of micelle delivery of mRNA
Data is from the University of Tokyo
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